Organism | UniProt | Comment | Textmining |
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Leptospira interrogans serovar Copenhageni | M3G1T5 | - |
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Leptospira interrogans serovar Copenhageni LT2050 | M3G1T5 | - |
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Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
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additional information | genome-wide mapping of LexA1 binding sites using ChIP-qPCR, determination of genes directly associated with LexA1 binding sites, overview. the LexA1 binding site is a 16 nt palindrome whose consensus is roughly CTnnACnnnnGTnnAG, it is present in all sequences shown to bind to LexA1 in serovar Copenhageni. Almost every peak of LexA1 binding is located upstream of a gene, in potential regulatory regions. LexA1-bound genes show decreased or no differential expression after DNA damage | Leptospira interrogans serovar Copenhageni | ? | - |
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additional information | genome-wide mapping of LexA1 binding sites using ChIP-qPCR, determination of genes directly associated with LexA1 binding sites, overview. the LexA1 binding site is a 16 nt palindrome whose consensus is roughly CTnnACnnnnGTnnAG, it is present in all sequences shown to bind to LexA1 in serovar Copenhageni. Almost every peak of LexA1 binding is located upstream of a gene, in potential regulatory regions. LexA1-bound genes show decreased or no differential expression after DNA damage | Leptospira interrogans serovar Copenhageni LT2050 | ? | - |
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Synonyms | Comment | Organism |
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LexA1 | - |
Leptospira interrogans serovar Copenhageni |
lexA_1 | - |
Leptospira interrogans serovar Copenhageni |
General Information | Comment | Organism |
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physiological function | isozyme LexA1 is probably the main regulator of the SOS response in Leptospira interrogans. In addition to both lexA genes and their operons, recA, recN and dinP are LexA1-bound and induced by DNA damage. LexA1 binds to the upstream sequence of both lexA1 and lexA2. Global transcriptional profiling during UV-C DNA damage response, overview. Two prophages heavily induce 12 h after UV-C irradiation involving LexA1 binding. Determination of LexA1 SOS box and DNA damage-inducible LexA1-bound genes | Leptospira interrogans serovar Copenhageni |